CD4 is a 55kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is a specific marker for T lymphocytes, monocytes, macrophages, and dendritic cells. Through interaction of MHC-II, CD4 facilitates cell-cell interaction, thymic differentiation, and activation of downstream signaling cascades. HIV infection of T-cells is instigated through binding of HIV to CD4. The OKT4 binds to the D3 domain of CD4 and does not inhibit HIV binding.
mFluor™ fluorescent labeling dyes are developed specifically for flow cytometry applications to enable optimal multi-color detection. These dyes are excellent alternatives to the phycoprotein-based tandems that are quite difficult to couple to an antibody or other biomolecules and offer greater light stability and brighter fluorescence. The mFluor™ 450 fluorophore is a great alternative to these dyes: V450, Pacific Blue™, VioBlue?, eFluor? 450, Brilliant Violet 421 and Super Bright 436. Do you need an antibody for an antigen you don't see on our website? Do you need a different conjugation than what we have listed? We have a wide selection of antigens with a variety of conjugations available. Please reach out to us at support@geneseesci.com.